• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The intelligent patch must be able to optimize the psychiatric treatment of panic disorder. This is achieved by injecting medication from the patch during initial seizures (by detecting elevated cortisol concentrations in the blood). The medicine inhibits the physical symptoms of the seizure so that patients are not distracted by them and deprived of the opportunity to practice the cognitive tools (to calm themselves during seizures) precisely in the situation where it is necessary to practice them. By giving patients the opportunity to first learn to tackle the psychological symptoms alone (and later the physiological symptoms on top of that when they stop using the patch), the challenge will be divided into smaller parts, and therefore with high probability be easier and less intimidating to overcome. This could potentially reduce treatment time, which would mean that those on the waiting list receive help more quickly, and the risk of them attempting suicide, developing agoraphobia or social anxiety would therefore most likely also be reduced (as these co-morbid tendencies most often develop when they morbidly anxious have not come into treatment yet).
    公开号:DK202000432A1
    申请号:DKP202000432
    申请日:2020-04-14
    公开日:2021-11-15
    发明作者:Vartiainen Josefine
    申请人:Vartiainen Josefine；
    IPC主号:
    专利说明:

    DK 2020 00432 A1 Description of the invention Anxiety disorders are an undeniably pronounced problem in our modern society - of which panic disorder is one of these common anxiety disorders and is estimated to affect about 2.7% of the western population in a continuous 12-month period and 1.2% 1 serious, morbid degree - of which 1 in 5 of panic sufferers attempt suicide if they do not receive a sufficient amount of an appropriate form of treatment.) But despite increasing focus on the topic in both the public debate and in the health science technological development, no technologies have been developed that are designed to help those suffering from panic disorder when the crisis is imminent, and they have a seizure as it is a severe anxiety disorder of coping as there is currently no. are definable causes of the seizures. Nor has anything been developed that aims to prevent the high risk of panic attacks developing agoraphobia (which 26% manage to develop) "while on the waiting list for treatment. Furthermore, it surprised me also how more in my social and family circle of acquaintances had to wait up to several months on the waiting list to be able to receive - treatment by a psychologist, ”and that so few options have been developed for medication for panic disorder that panic anxiety is virtually no option have to get medical help to relieve their seizures exclusively, since the pro necessitate designed sedatives that are available only have an efficacy after at least 30 minutes after ingestion - making them useless for most panic-disorder sufferers, as only a few with panic disorder have seizures that last longer than that, due to the aforementioned, there are therefore many panic disorder sufferers who receive other medications eg antidepressant medication and the like, but which has an effect at all hours of the day (although panic disorder is caused by isolated seizures, which can be up to several weeks apart) and therefore also very intense side effects (and it surprised me that there were no - developed a better alternative, which has a better format for the disorder). "" 'I was frustrated to understand that this problem has not been prioritized enough to develop a strategy for how to prevent it. or developed alternative methods of how to minimize the major consequences for the panic-stricken (such as the high risk of suicide attempts and the development of disabling agoraphobia), which wait several months - waiting list for help. My project is unique and innovative because it designs an idea for a medical technology that could potentially help this particular vulnerable target group.
    1
    DK 2020 00432 A1 I propose a project for the development of an intelligent, transdermal patch with nanotechnological functions and properties, such as MEMS (microelectro-mechanical systems) and biosensing, which will be offered to those who receive psychiatric treatment for panic disorder, which will form help them relieve the physical symptoms of the seizures when they occur. The powerful and frightening symptoms can cause patients to be distracted the moment they have the seizure and deprived of the chance to practice the use of the cognitive tools they receive in therapy during treatment, which are necessary for them to eventually be able to to learn to tackle the panic attacks myself - which I, together with two experienced psychiatrists, 40 I have met with from Rigshospitalet's Psychiatric Department and Amagers Psychiatric Center, respectively, believe could help the sick individuals learn to master the use of the tools faster, than is possible at present (as the physical symptoms also tend to aggravate the psychological symptoms and thus make the challenge even greater when patients in treatment have to learn to use the tools).
    45 - My project idea could technically be described as a general-size patch, which is covered with about 200 micro-needles (of the type through which there are channels), each of which is 0.5 mm. long (so it just feels like sandpaper against the skin and is not painful to apply). The microneedles, which are on one side of the patch, must be lined with an enzymatic, electrochemical biosensor, which can measure when the concentration of cortisol in the blood is particularly high (which is 50 - the case during an anxiety attack) and the values for concentration, which must exceeded for an individual (which differs from patient to patient), I have calculated a model for (they are found in my report but are not considered necessary in this application). When the values are exceeded, a microelectromechanical system (MEMS), in the form of an electrostatic micropump, receives a signal from the sensor, and a dose, 1 mg, is then pumped "to block 55 (Propranolol) from any reservoir in the patch into the bloodstream through the rest of the microneedles, which alleviate the physical symptoms that the panic sufferer experiences during their seizures (and the dose is considered highly likely to be safe to use, since it is the same that is otherwise used to, for example, reduce heart rate in surgical patients) " É. Visualization of the patch and its function is seen in Figure 1 of the document: drawings. The patch will 60 - furthermore be expected to optimize the waiting time for the drug to take effect, as the drug that would be used (Propranolol, which inhibits the physical symptoms anxiety symptoms by inhibiting the neurotransmitter norepinephrine), since today it can only be received by individuals in pill form and taking 30 minutes for the effect to occur (as it must reach 2
    DK 2020 00432 A1 be taken orally, into the stomach and then diffuse into the bloodstream). However, with this 65 patch, which delivers the drug transdermally, it will be injected directly into the bloodstream through the microneedles and thus most likely have a markedly faster efficacy (when Propranolol is injected in situations where surgical patients have elevated heart rate during surgery, it takes less than a minute before it has its effect). " Since the patch must be able to make continuous measurements of the patient's cortisol concentration in the blood at all hours of the day, the 70 - the patch must have a plastic coating that will act as a shell that ensures that water can not enter the patch, so he can also use plastered in the bathroom.
    The different parts that the patch consists of: 75 - In order to be able to argue that the patch is feasible, I have taken as my starting point different versions of the different sub-elements, which have already been developed and have a documented effect.
    The unique thing about this project is therefore the composition of all the sub-elements in a new system (in the form of an intelligent patch), so that they can have a new purpose by working together.
    80 The biosensor of the patch: The biosensing in the intelligent patch is one of the essential mechanisms that must be responsible for the monitoring of the cortisol concentration in the blood. There are many different types of 85 biosensors that can measure many different analytes in different ways. In the project, I investigated three potential electrochemical biosensors to use in the patch, and based on the assessment of their different characteristics of function, assessed which type of biosensor would be best to incorporate in the patch: which became the electrochemical biosensor, which has enzyme as receptor .
    90 - Electrochemical biosensors are those biosensors that convert biochemical information (such as analyte concentrations) into an analytically useful signal: current or voltage, which can then be processed. Jobst Technologies GmbH is a German company and has decades of experience with enzymatic biosensors. They use a technique where the enzymes are immobilized in a stack of four permeable polymer membranes on top of some platinum microelectrodes that are affected by 95 - the electronegativity that changes during the reaction that occurs and can be measured when the enzyme 3
    DK 2020 00432 A1 binds to the cortisol and reacts with it.
    The superior membrane technology that has been developed at Jobst Technologies results in increased sensitivity, response time and measurement interval. ” A research team of three from mainland China and two from Taiwan developed, in collaboration with the German company, Jobst Technologies GmbH, in December 2019 a biosensor that measured cortisol at
    100 use of enzyme.
    However, it was not stated in the report which enzyme was used, but the enzyme 11-beta HSD is known to react with cortisol and convert it to cortisone.
    When the enzyme converts the cortisol to cortisone, the electrodes in the two-dimensional nanoflags that sit up by the enzyme will receive a chemical signal (due to the electronegativity of the analyte temporarily changing when it is multiplied to cortisone) and the signal will be sent thereby.
    105 - on to MEMS. "
    Plastic MEMS (micro-electro-mechanical system): MEMS stands for Micro Electro Mechanical System and can generally be perceived as having
    110 two main mechanisms: called sensors and acturators respectively.
    The difference between them is that sensors collect information from their surroundings, while actuators perform practical tasks under very controlled movements, depending on what information the sensors have captured.
    These are connected to an I.C part, ("integrated circuits"), which acts as the processor in the MEMS chip.
    While MEMS transducers sense or control
    115 - physical, optical or chemical quantities, ICs typically provide functionalities related to the signals from these transducers "Hi Generally, MEMS chips are made of thin layers of different materials, which are added together, which are then ground - so that a three-dimensional structure with layers of the different materials to be used.
    These materials can be both electronic and
    120 - mechanical, and they have different functions: the electronic materials process data while the mechanical materials act on the basis of given data.
    X It is a micro-electro-mechanical system in the form of a micro-pump, which is relevant for use in the patch (as it must receive a signal from the biosensor to pump 1 mg of Propranolol through the microneedles). And since there are many different kinds of micropumps, there are five
    125 - the function of different types of micropumps has been compared in my report (both mechanical and non-mechanical pumps) and it was based on the comparison that it is the
    4
    DK 2020 00432 A1 electrostatic micropump, which is most obvious to use in the patch. Zengerle has developed and published a report on an electrostatic micropump with control valves, which I have taken as a starting point in my project. The reported micropump consists of a silicon diaphragm.
    130 The maximum pressure reached 31 kPa. The maximum flow rate was 850 l / min. x! The structure of the pump can be seen in Figure 2 of the document: bills, and is one of the figures from the report by Zengerle.
    The diaphragm in the electrostatic micropump will be able to change its structure, depending on whether it is applied voltage or not. * The deformed diaphragm is restored if the applied 135 voltages are switched off. Thus, the volume of the patch's drug reservoir inside the micropump changes at each half cycle with periodic change of applied voltage. The liquid in the reservoir is forced to flow out through the channels in the microneedles due to the pressure difference which is due to the momentum of the membrane * ¥ i! The electrostatic force applied to the electrostatic plate can be described as 140 - the following: Ax x2 where F is the electrostatic force of attraction, W the stored energy, € the electrical constant, A the electrode area, X is the distance between the electrodes and V is the applied excitement.
    145 Esktra function: since the cortisol concentration in the body varies during the day and the size of the variation may differ from person to person, it will be necessary for the MEMS chip to be calibrated to the patient's non-elevated (normal) concentrations during the day, so that it only are the exact values, which are measured to be higher than these, which must be recorded as an indicator of initial seizures. The values (for non-elevated 150 - concentrations of cortisol) to which the MEMS is calibrated must be exceeded before a seizure is indicated, must be defined by the patient (who wishes to use the patch) making some saliva samples (where the tube is marked with time of day to salivate i) in each waking hour for 7 days, after which the samples are sent to a laboratory where an analysis of the samples (eg quantitative lateral flow assay) defines which concentrations of 155 - cortisol, which are normal for the individual to have during the day. Once the values are found, the chip in the micropump would need to be calibrated to these values (given in hourly intervals) so that it
    DK 2020 00432 A1 ensures that the micropump does not register a concentration of cortisol in the blood as being a "sign of seizures" at a given time, which is actually quite normal for the person to have at that time of day. 160 The microslip of the plastic: Microneedles are microscopic-sized needles that are small enough to measure in millionths of a meter (μm), designed to deliver medicine. They penetrate only the outer 10-50um of the skin layer (called stratum corneum) and therefore dermal nerves and blood vessels are not affected so there is 165 no pain or bleeding involved when the patch is applied (it will just feel like velcro or a cat tongue against the skin ). Once the needles have penetrated the skin layer, microscopic pores are created, which allow the medicine to enter the body. ¥ * In the late 1990s, research groups around the world made microneedles from several different types of materials (ranging from metal, silicon to glass). By bypassing the outer layer of the skin, 170 - microneedles could create an easier passage to the rich blood supply in the lower dermal layers, enabling easy, painless delivery of a wide variety of drugs through the skin. Typically, several needles are grouped together so that it can be designed to be applied to the skin as a patch "+ There are generally four different types of microneedles used for transdermal medicine delivery: 175 1. The rigid needle used to make the medicine side on the surface of the skin, and even move down into the skin through the holes that the needles make.
    The medicine-coated needle, which ensures that the medicine is down into the skin when the needles penetrate the pores.
    The soluble needle, which dissolves completely or partially when in the skin. 180 4. The needle with channel through which can release medicine from an associated reservoir. In the report, I have explained, compared and discussed the advantages and disadvantages of 3 different types of microneedles (can be documented if required), and I have come to the conclusion that it is the microneedle with channel through which is best suited for use in the patch. The needles should be 185 - be 0.5 mm. long and be made of silicone as it does not irritate the skin and will therefore be able to sit in the skin for longer periods without problems and at the same time will be a flexible enough material that the needles would not break if the patch is not placed perpendicular to the skin. 6
    DK 2020 00432 A1 What type of sedative will be best for use in the patch 190 I have researched the different types of medications that have a calming effect and are used to treat anxiety. And there are several types of medications that have a calming effect and can benefit people living with various anxiety disorders. Beta-blockers are used in connection with anxiety to inhibit the neurotransmitter norepinephrine, so the medicine especially inhibits the physical symptoms of anxiety: such as palpitations, suffocation, 195 - shaking of the hands and pain or pressure in the chest. The medicine therefore does not influence the individual's hormonal, chemical imbalance, but helps the person deal with the physical symptoms. "" Therefore, the best medicine to use in the patch is precisely this, since the premise for use in the patch is precisely that the medicine should only have a calming effect on the physical symptoms (since the purpose is that the first step in the treatment should only be to learn to 200 tackle the psychological symptoms of the seizure to make the challenge smaller (by dividing it into smaller parts) and then afterwards to learn to tackle the physical ones on top, by stopping the use of the patch).
    Furthermore, I have also calculated the half-life of Propranolol, and concluded what influence it will have on the function of the patch in connection with. how often it can inject a maximum of 205 - Propranolol, so as not to result in an overdose (the calculations can be documented if required). The conclusion was that a maximum of 1 mg Propranolol per fourth hour, so as not to exceed the maximum dose that the body can handle. Therefore, the micropump will be set not to measure cortisol 4 hours after each injection of Propranolol - which should not be a problem since the drug has its effect for 3 to 4 hours after onset.
    210 - After all the medicine's reservoirs of medicine have been used, it must be possible to remove the empty reservoirs, after which a new plate will be able to be “clicked” on the plaster with filled reservoirs.
    ‘Memon, Mohammed. & Welton, Randon .; Panic Disorder (2018) ii Reed, Victoria. & Wittchen, Hans; Dsm-iv panic attacks and panic disorder in a community sample of adolescents and young adults: how specific are panic attacks (1998) tiGoodwin RD, Faravelli C, Rosi S, Cosci F, Truglia E, de Graaf R: The epidemiology of panic disorder and agoraphobia in Europe. Eur Neuropsychopharmacol 2005; 15: 435-43 Due, Henning .; Record-long waiting time for psychologist treatment, Danish Psychologists Association 7
    Y Videbech, Poul; Panic Disorder, Treatment (2019) at the Mayo Clinic; Selective serotonin reuptake inhibitors (SSRIs) (2019) vit Faigel, HC .; The effect of beta blockade on stress-induced cognitive dysfunction in adolescents.
    Clin Pediatr (1991) Vili Sinha, Sanjai .; Propanolol (2019) https Awww drugs conypoa / propranejol hun] ix Sinha, Sanjai .; Propanolol (2019) * Xinke, Liu, P, Hsu., Wai-Ching, Liu., Yi-Min, Wang., Xinrui, Liu., Ching-Shu, Lo., Yu-Chien, Lin., & Sasza, Nabilla .; Salivary Electrochemical Cortisol Biosensor Based on Tin Disulfide Nanoflakes (2019) x Xinke, Liu, P, Hsu., Wai-Ching, Liu., Yi-Min, Wang., Xinrui, Liu., Ching-Shu, Lo., Yu- Chien, Lin., & Sasza, Nabilla .; Salivary Electrochemical Cortisol Biosensor Based on Tin Disulfide Nanoflakes (2019) "in Fischer, Andreas., Forsberg, Fredrik. & Lapisa, Martin .; Integrating MEMS and ICs (2015) bps www. Reseamheate sede Vis Bryst» holero gg neoyug yegratton platform fro InyenSenses Ing San Jose Cår USA flet3 277974622 xii MEMS- industry group; Introduction to MEMS "Micro-Electro-Mechanical System" (2009) xv MEMS- industry group; Introduction to MEMS "Micro-Electro-Mechanical System" (2009) "> R.
    Zengerle, J.
    Ulrich, S.
    Kluge, M.
    Richter, A.
    Richter, A bidirectional silicon micropump, Sens.
    Actuators A: Phys. 50 (1995) 81—86. »IR, Zengerle, J.
    Ulrich, S.
    Kluge, M.
    Richter, A.
    Richter, A bidirectional silicon micropump, Sens.
    Actuators A: Phys. 50 (1995) 81—86. »IR, Zengerle, J.
    Ulrich, S.
    Kluge, M.
    Richter, A.
    Richter, A bidirectional silicon micropump, Sens.
    Actuators A: Phys. 50 (1995) 81—86. wii A Nisar., Nitin, Afzulpurkar., Banchong, Mahaisavariya., & Adisorn, Tuantranont .; MEMS-based micropumps in drug delivery and biomedical applications (2008) xx Quinn, Helen .; Explainer: what are microneedles and why do we need them (2016) x Quinn, Helen .; Explainer: what are microneedles and why do we need them (2016) x Quinn, Helen .; Explainer: what are microneedles and why do we need them (2016) wii Rosenberg, Raben; Medicine for anxiety (2019) Bibliography: A.
    Nisar, Nitin.
    Afzulpurkar, Banchong.
    Mahaisavariya & Adisorn, Tuantranont.
    MEMS-based micropumps in drug delivery and biomedical applications.
    Year. 130, in Sensors and Actuators B: Chemical.
    Klong Luang: Elsevier, 2008. 8
    DK 2020 00432 A1 Anonymous. Mayo Clinic. 17. 09 2019. https://www.mayoclinic.org/diseases-conditions/depression/in- depth / ssris / art-20044825 (last retrieved or viewed on 05. 12 2019).
    Introduction to MEMS "Micro-Electro-Mechanical System". Directed by ElectronDZ. Produced by Youtube. 2009.
    Faigel, HC. "The effect of beta blockade on stress-induced cognitive dysfunction in adolescents." (Clinical Pediatric) 30, No. 7 (1991).
    Fischer. Andreas, Forsberg. Fredrik & Lapisa. Martin. ResearchGate. 05 2015. https: //www.researchgate net / figure / Via-first-heterogeneous-integration-platform-from- InvenSense-Inc-San-Jose-CA-USA figl3 277974622 (last retrieved or viewed on 01 2020).
    Association, Danish Psychologist. Danish Psychologist Association. 20. 07 2017. https://www.dp.dk/rekordlang- ventetid-til-psykologbehandling / (last retrieved or shown on 11. 10 2019).
    Goodwin RD, Faravelli C, Rosi S, Cosci F, Truglia E, de Graaf R. »The epidemiology of panic disorder and agoraphobia in Europe.« Eur Neuropsychopharmacol., 2005: 435-43.
    Memon, Mohammed. Medscape. 21. 03 2018. https: // emedicine medscape.com/article/287913- overview (last retrieved or viewed on 20. 10 2019).
    Quinn, Helen. The Conversation. Creative commons. 18. 03 2016. https://theconversation.com/explainer-what-are-microneedles-and-why-do-we-need-them- 54623 (last retrieved or viewed on 05. 01 2020).
    R. Zengerle, J. Ulrich, S. Kluge, M. Richter, A. Richter. »A bidirectional silicon micropump.« (Sens. Actuators) 50 (1995).
    Rosenberg, Raben. Drugstore. apoteket.dk. 2019. https://www.apoteket.dk/medicin/medicinsk-behandling / psykiske-lidelser / medicin-mod-angst (last retrieved or shown on 10. 02 2020).
    Sinha, Sanjai. Drugs.com. 21. 10 2019. https://www.drugs.com/ppa/propranolol html (last retrieved or viewed on 10. 01 2020).
    Videbeck, Poul. sundhed.dk. 13. 08 2019. https: //www.sundhed dk / borger / patienthaandbogen / psyke / sjukdomme / angsttilstande / panikang st -behandling / (last downloaded or shown on 22. 11 2019).
    Wittchen, V. Reed & H. »Dsm-iv panic attacks and panic disorder in a community sample of adolescents and young adults: how specific are panic attacks « Journal of Psychiatric Research, 1998: 335-345.
    Xinke, Liu., P, Hsu., Wai-Ching, Liu., Yi-Min, Wang., Xinrui, Liu., Ching-Shu, Lo., Yu-Chien, Lin, & Sasza, Nabilla. »Salivary Electrochemical Cortisol Biosensor Based on Tin Disulfide Nanoflakes.« (Nanoscale Research Letters) 189 (2019).
    9
    权利要求:
    Claims (10)
    [1]
    An unintelligent patch with a biosensor that can measure the concentration of cortisol in the bloodstream and with a MEM system secrete a dose of sedative into the blood by measuring concentrations that have been defined as elevated (and thus are an indicator of initiating panic attacks).
    [2]
    According to any one of the preceding claims, the biosensor of the patch must have enzyme as receptor. And since the patch with the biosensor must be able to make continuous measurements of the patient's cortisol concentration in the blood at all hours of the day, the patch must have a plastic coating that will act as a shell that ensures that water can not enter the patch so that the patient can also use the patch in the bathroom.
    [3]
    According to any one of the preceding claims, the MEMS of the patch must be an electrostatic micropump.
    [4]
    According to each of the preceding claims, the MEMS must be calibrated, before use, to precisely the cortisol values which are defined as "normal" for the patient (and thus it will only be by measuring a higher value than what is defined as normal for the person to have at a given time that the micropump pumps medicine into the bloodstream).
    [5]
    According to each of the preceding claims, the values (for non-elevated concentrations of cortisol) to which the MEMS is calibrated must be exceeded before indicating an initial seizure, defined by the patient performing some saliva samples (where the tube is marked with time of day to salivate i) in each waking hour for 5 days, after which the samples are sent to a laboratory where analysis of the samples (eg quantitative lateral flow assay) defines which concentrations of cortisol are normal for the individual to have during the day.
    [6]
    According to any one of the preceding claims, the electrostatic micropump should pump 1 mg of Propranolol transdermally through any hollow microneedles into the bloodstream at a flow rate not exceeding 1 mg / min.
    [7]
    According to any one of the preceding claims, the needles must be 0.5 mm. long and be made of silicone so that they do not irritate the skin and at the same time will be a flexible enough material that the needles would not break if the patch is not placed perpendicular to the skin when the patch is applied.
    DK 2020 00432 A1
    [8]
    According to any one of the preceding claims, the patch must be used for psychiatric treatment of panic disorder patients.
    [9]
    9. The MEMS is set not to detect a cortisol concentration signal 4 hours after injecting medication (to avoid overdose).
    [10]
    According to each of the preceding requirements, a new plate with filled reservoirs of medicine must be able to be "clicked" on the patch after all reservoirs have been emptied.
    类似技术:
    公开号 | 公开日 | 专利标题
    Li et al.2013|An optimized hollow microneedle for minimally invasive blood extraction
    Roxhed et al.2008|Painless drug delivery through microneedle-based transdermal patches featuring active infusion
    TW592661B|2004-06-21|Percutaneous biological fluid sampling and analyte measurement devices and methods
    ES2831602T3|2021-06-09|Integrated injection system and communications device
    JP6549991B2|2019-07-24|Biologically tunable bioactive agent delivery device
    Naaman et al.2009|Coping with early breast cancer: Couple adjustment processes and couple-based intervention
    US20040147906A1|2004-07-29|Implantable interface system
    AU2016211330A1|2017-08-03|Drug delivery methods and systems
    US20030135166A1|2003-07-17|Switchable microneedle arrays and systems and methods relating to same
    US20120143021A1|2012-06-07|Device, system and method for meal detection for interfacing with and controlling auxiliary devices associated therewith
    Lee et al.2018|A three-dimensional and bevel-angled ultrahigh aspect ratio microneedle for minimally invasive and painless blood sampling
    JP4626700B2|2011-02-09|Biological rhythm information acquisition method
    KR20010006147A|2001-01-26|Minimally invasive detecting device
    DK180669B1|2021-11-15|INTELLIGENT PLASTER as a new initiative for personalized medical technology: Automation of medication management for individuals suffering from panic disorder.
    Xiang et al.2015|Development of a flexible and disposable microneedle-fluidic-system with finger-driven drug loading and delivery functions for inflammation treatment
    WO2018100176A1|2018-06-07|Cartridge for biochemical sensor
    Darvishha et al.2019| dermal insulin delivery based on polymeric systems
    US20210321916A1|2021-10-21|Actuator system
    Sawon et al.2021|Design and optimization of a microneedle with skin insertion analysis for transdermal drug delivery applications
    Shivanand et al.2009|Microneedles: progress in developing new technology for painless drug delivery
    CN201445525U|2010-05-05|Dialysis puncture bleeding monitor
    Siegel et al.2009|Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices
    JP2009536542A|2009-10-15|Device for drug administration and / or patient condition monitoring
    Anderson et al.2017|Design of functionalized materials for use in micronanoscale drug delivery devices and smart patches
    Schoonen et al.2005|Glucose transport in adipose tissue
    同族专利:
    公开号 | 公开日
    DK180669B1|2021-11-15|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    法律状态:
    2021-11-15| PAT| Application published|Effective date: 20211015 |
    2021-11-15| PME| Patent granted|Effective date: 20211115 |
    优先权:
    申请号 | 申请日 | 专利标题
    DKPA202000432A|DK180669B1|2020-04-14|2020-04-14|INTELLIGENT PLASTER as a new initiative for personalized medical technology: Automation of medication management for individuals suffering from panic disorder.|DKPA202000432A| DK180669B1|2020-04-14|2020-04-14|INTELLIGENT PLASTER as a new initiative for personalized medical technology: Automation of medication management for individuals suffering from panic disorder.|
    [返回顶部]